Technical Program
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| Start Time | End Time | |
| October 14, 2024 | All Pacific Standard Time | |
| Day 1 | ||
| 8:00 AM | 4:00 PM | Registration |
| 9:00 AM | 9:10 AM | Welcome Remarks by Chairs: |
| 9:10 AM | 10:00 AM | KEYNOTE: Multiplex editing for medicine, agriculture, and eco-conservation, George Church, Harvard Medical School and MIT |
| 10:00 AM | 10:30 AM | Morning Coffee Break |
| 10:30 AM | 12:00 PM | Session 1: Commercial Translation of Gene Editing (Panel) Moderators: Tanya Warnecke, & Jonathan Yen |
| 10:30 AM | 10:45 AM | Moderator Introduction: Tanya Warnecke, Codebreaker, Jonathan Yen, St. Jude Hospital |
| 10:45 AM | 11:00 AM | Invited Speaker/Panelist: Enhancing in vivo genome and transcriptome engineering, Prashant Mali, UCSD |
| 11:00 AM | 11:15 AM | Invited Speaker/Panelist: Vern Norviel, Wilson Sonsini |
| 11:15 AM | 11:30 AM | Invited Speaker/Panelist: Ajay Kshatriya, Wilson Hill Ventures |
| 11:30 AM | 11:45 AM | Pitch your innovation for up to $2 million in grant funding, Erik Pierstorff, National Science Foundation |
| 11:45 AM | 11:55 AM | 10 Minute Stretch Break |
| 11:55 AM | 12:55 PM | Q&A Panel with Panelists: Prashant Mali, UCSD, Vern Norviel, Wilson Sonsini, Ajay Kshatriya, Wilson Hill Ventures |
| 12:55 PM | 1:55 PM | Lunch |
| 1:55 PM | 3:15 PM | Session 2: Natural Biology of CRISPR Systems Session Chair: Weixin Tang & Greg Newby |
| 1:55 PM | 2:20 PM | Invited Speaker: Reengineering CRISPR-Cas effector complexes, David Taylor, UT Austin |
| 2:20 PM | 2:45 PM | Invited Speaker: Cas9 and Cas12a effector destruction by anti-CRISPR proteins enables phage-CRISPR symbiosis, Joseph Bondy Denomy, UCSF |
| 2:45 PM | 3:00 PM | Selected Abstract: Interpreting CRISPR-Cas12a Enzyme Kinetics through Free Energy Change of Nucleic Acids, Jiongyu Zhang, University of Connecticut Health Center |
| 3:00 PM | 3:15 PM | Selected Abstract: Structure-Guided Discovery of Ancestral CRISPR-Cas13 Ribonucleases, Zeyuan (Terry) Zhang, UC Berkeley |
| 3:15 PM | 3:45 PM | Afternoon Coffee Break |
| 3:45 PM | 5:40 PM | Session 3: Cross-Kingdom Applications of CRISPR Session Chairs: Ian Wheeldon, Carrie Eckert & Xue (Sherry) Gao |
| 3:45 PM | 4:10 PM | Invited Speaker: CRISPR-enabled functional genomics for non-model organisms in the circular bioeconomy, Carrie Eckert, ORNL |
| 4:10 PM | 4:35 PM | Invited Speaker: Data-driven design and optimization of genome-wide CRISPR screens, Ian Wheeldon, UCR |
| 4:35 PM | 5:00 PM | Invited Speaker: Engineered CRISPR systems for drug discovery, Xue (Sherry) Gao, University of Pennsylvania |
| 5:00 PM | 5:25 PM | Invited Speaker: Expanding The CRISPR Genetic Engineering Toolkit In Plants, Gozde Demirer, CalTech |
| 5:25 PM | 5:40 PM | Selected Abstract: A Multi-Kingdom Technology Development Pipeline Delivers Templated Editing and Other CRISPR Tools for Making Novel Crop Traits, Joseph Watts, Pairwise |
| 5:40 PM | 6:40 PM | Poster Session 1 + Cocktail Reception |
| October 15, 2024 | All Pacific Standard Time | |
| Day 2 | ||
| 8:00 AM | 4:00 PM | Registration |
| 9:00 AM | 9:10 AM | Welcome Remarks by Chairs: |
| 9:10 AM | 10:00 AM | KEYNOTE: Genome Engineering: a journey in target discovery technologies, Ryan Gill, Codebreaker |
| 10:00 AM | 10:30 AM | Morning Coffee Break |
| 10:30 AM | 12:15 PM | Session 4: Beyond Double Stranded Breaks: Enabling Genome Engineering Session Chairs: Weixin Tang, & Samagya Banskota |
| 10:30 AM | 10:55 AM | Invited Speaker: Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing, Daniel Gao, Harvard University |
| 10:55 AM | 11:20 AM | Invited Speaker: Small Nuclear RNAs Enhance Endogenous Protein-Mediated RNA-Programmable Base Conversion On Mammalian Coding Transcripts, Aaron Smargon, UCSD |
| 11:20 AM | 11:45 AM | Invited Speaker: Understanding the Molecular Mechanism of Genome Editors to Enhance their Precision and Targeting Scope, Audrone (Audrey) Lapinaite, UC Irvine School of Medicine |
| 11:45 AM | 12:00 PM | Selected Abstract: Next-Generation CRISPR Epigenetic Editing Technologies and Delivery Platforms, James Nu帽ez, UC Berkeley |
| 12:00 PM | 12:15 PM | Selected Abstract: Engineering RNA Tools to Control Individual Microbes and Microbiota without Antibiotic Resistance Genes at a Single Strain Level, Tae Seok Moon, J. Craig Venter Institute |
| 12:15 PM | 1:15 PM | Lunch |
| 1:15 PM | 2:35 PM | Session 5: Assessing Safety in Genome Editing for Clinical Applications Session Chairs: Tanya Warnecker & Melissa Bonner |
| 1:15 PM | 1:40 PM | Invited Speaker: Human genetic diversity alters therapeutic gene editing off-target outcomes, Luca Pinello, Harvard Medical School |
| 1:40 PM | 2:05 PM | Invited Speaker: High throughput detection of cellular genome-wide activity of Cas9 with pooled GUIDE-seq-2, Azusa Matsubara, St. Jude |
| 2:05 PM | 2:20 PM | Extended Guide RNAs (x-gRNAs) with Personalized Extensions Significantly Enhance CRISPR Specificity, Eric Josephs, Stony Brook University |
| 2:20 PM | 2:35 PM | Selected Abstract: An Expedited Workflow for the Development of Personalized Base-Editng and Prime-Editing Therapies for Inborn Errors of Metabolism, Xiao Wang, University of Pennsylvania |
| 2:35 PM | 3:05 PM | Afternoon Coffee Break |
| 3:05 PM | 4:50 PM | Session 6: Delivery Modalities Session Chairs: Samagya Banskota & Greg Newby |
| 3:05 PM | 3:30 PM | Invited Speaker: Enabled Directed Evolution of Vaccinia for Enhanced Delivery as an Oncolytic Virotherapy, David Schaffer, UC Berkeley |
| 3:30 PM | 3:55 PM | Invited Speaker: Maximizing Yields of Highest Quality Cells with Flowfect, Lauren Kinner, Kytopen |
| 3:55 PM | 4:20 PM | Invited Speaker: Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant hematopoietic stem cells, Xizhen Lian, JHU |
| 4:20 PM | 4:35 PM | Selected Abstract: Assessing and Engineering the Iscb-惟rna System for Programmed Genome Editing, Hao Yan, University of Chicago |
| 4:35 PM | 4:50 PM | Selected Abstract: A "One-and-Done" CRISPR Therapeutic for Huntington's Disease and Other Repeat Expansion Diseases, Ricardo Mouro Pinto, Massachusetts General Hospital & Harvard Medical School |
| October 16, 2024 | All Pacific Standard Time | |
| Day 3 | ||
| 8:00 AM | 12:00 PM | Registration |
| 9:00 AM | 9:10 AM | Welcome Remarks by Chairs: |
| 9:10 AM | 10:00 AM | KEYNOTE: Precision Epigenome Editing for Gene Therapy, Stanley Qi, Stanford University |
| 10:00 AM | 10:30 AM | Morning Coffee Break |
| 10:30 AM | 12:00 PM | Session 7: AI, Genomics, and Gene Editing Tools Session Chairs: Weixin Tang, & Ryan Gill |
| 10:30 AM | 10:55 AM | Invited Speaker: Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences, Peter Cameron, Profluent |
| 10:55 AM | 11:20 AM | Invited Speaker: Development of cytosine base editors by discovery of deaminase functions through structure-based protein clustering, Kevin Zhao, QiBio |
| 11:20 AM | 11:45 AM | Invited Speaker: Overcoming The Risks In Biochemical Product Development and Manufacturing Through Rapid Genome Scale Metabolic Engineering, Richard Fox, Inscripta |
| 11:45 AM | 12:00 PM | Selected Abstract: Innovative CRISPR Reagents for Gene Editing and Homology-Directed Repair (HDR): Paving the Way to Clinical Success, Karthik Murugan, Integrated DNA Technologies, Inc. (IDT) |
| 12:00 PM | 12:10 PM | Closing Remarks by Chairs |
