91成人短视频

Session Chairs:

• Stacie Santhany, The Dow 91成人短视频 Company
• Anne Mohan, Merck

The poster reception will feature a mix of poster presentations from both industry and academia. As attendees mingle between posters, Hors d'oeuvres and drinks will also be served.

Schedule:

Abstracts:

DuPont鈥檚 Competitive Edge in Process Development: Virtual Plant Technology

Tracy L. Clarke-Pringle* and John Bomberger, DuPont

DuPont鈩� TMODS is DuPont鈥檚 most widely used dynamic process simulator, with a history of more than 20 years, over 400 users and hundreds of applications. It has been used in support of all aspects of a plant鈥檚 life cycle, including process conceptualization, process and control strategy development, vendor automation validation, operator training, and process optimization. Over the years, it has been used to create 鈥淰irtual Plants鈥� for a wide range of batch and continuous processes: from small molecule, to polymer. Most recently, it has been used in the conceptualization, cost estimation, and design of new bio-processes.

These applications of dynamic process simulation together define the field of Virtual Plant Technology, in which DuPont has a strong competitive advantage. Virtual Plant Technology can be considered to be a 鈥渇light simulator鈥� for chemical, polymer, and bio-processes, allowing scientists and engineers to interact with the Virtual Plant as if it was the real process, and permitting the safe and efficient exploration of any number of process design, control, or operating changes. This poster will provide an overview of DuPont鈥檚 application of Virtual Plant Technology with a focus on process development, and including a live demonstration of TMODS to illustrate key ideas.

Solvent Selection for Fine 91成人短视频 Process Development

David Couling*, Jason Fisk, Brian Murdoch, Melissa Hays, Abe Schuitman, Ron Leng, Adam Grzesiak, and Megan Donaldson, The Dow 91成人短视频 Company

Solvent selection can have a profound impact on the viability of a fine chemical process, from reaction performance to product recovery to waste management.  In many instances, the path toward economic viability also ensures that the process is sustainable, exhibited by higher product yields and reduced waste footprints.  Here an overview of the solvent selection process, along with the analytical tools to evaluate the selections, will be presented for the process development of a recent fine chemical process.

Solid-Liquid Separations Process Development

Susanne Wolff, DuPont

Sustainable 鈥済reen鈥� processes such as natural product purification, fermentation, and enzymatic-catalyzed reactions frequently require solid-liquid separations steps in both the upstream feedstock preparation and downstream product purification.  Applicable filtration and centrifugation technologies often exist but are costly, requiring multiple steps, stream conditioning, and process development to specify and optimize.  Laboratory development is challenged by difficulties in obtaining representative feed samples and limited ability to accurately investigate filter media lifetime, polishing, solids conveyance, recycle effects etc.  Pilot operation of solid-liquid separation steps is essential to ensure commercial scale-up success.  A fully integrated pilot plant provides the highest degree of risk mitigation but requires cost justification.  The pilot step is of particular importance for processes utilizing bio-derived feed stocks where material properties change with time, particles are present, and impurity profiles are significant and more varied than traditional chemical industry feed stocks.

Batch-to-Continuous Process Development: Continuous Emulsion Aggregation Formation of Composite Polymeric Particles

David Lawton, Xerox Research Centre of Canada

Emulsion aggregation is the process of bringing nano-sized polymer particles together through controlled orthokinetic aggregation and particle coalescence in an aqueous solution. The process of building larger particles from smaller particles allows for much greater control of particle size distribution when compared to the classical method of size-reduction and classification of larger particles.  Starting with nano-sized particles also allows for composite particles to be created as well as the formation of core-shell morphologies.  Originally developed as a batch-process, work at the Xerox Research Centre of Canada (XRCC) has developed a fully-continuous process enabling greatly increased process space-time yields. This poster presents work in the development of the Continuous Aggregation Process (CAP) which utilizes a XRCC-designed Agitated Reactor Column (ARC). This 鈥楢RC鈥� was designed and optimized using the aid of computational fluid dynamics (CFD) to facilitate plug-flow behaviour in the axial direction, while maintaining a high-shear/well-mixed flow in the radial and tangential axial directions of flow.

The Influence of Mixing in the Process

Dinesh Malviya, Visimix

It is a well-known fact that 91成人短视频 production is a result of several chemical reactions and purification steps. Purification steps and processes yield are a direct function of the level of understanding of the reaction system. Reaction quality results have a tremendous impact in separation technology. 91成人短视频 production is frequently performed on stirred vessels that are operated at batch or semi-batch configuration. The choice process configuration is determined at the development stage of the project. Therefore, if the chemical reaction and mixing are not well understood, wrong selections will be adopted in the process development. Our goal is to develop a method, based on calculated parameters that will run properly in the first trial on a new scale or site, similar to our successful results in the lab or in the old facility. The financial impact of understanding the chemical reaction was assessed.

Inkjet Printing: 91成人短视频 Product and Process Design

Kevin Joback, Molecular Knowledge Systems

With more than 70 million printers sold each year, inkjet printing is a familiar technology for producing digital images. However, most people do not realize the complicated processes and products needed to produce a single character on a sheet of paper. Inkjet inks are complex formulations of colorants, solvents, surfactants and polymers. Rapid heat transfer causes these solvents to explosively evaporate ejecting the ink through thousands of microscopic nozzles in a small fraction of a second. The droplets of ink deform and coalesce as they travel the short distance between the nozzle and the substrate. Upon impact the ink drop must flow across the substrate in a controlled manner as some of the ink permeates into the paper. Finally the ink must rapidly dry leaving the pigments and dyes well adhered to the sheet of paper.

Today inkjet technology is being used to print more than documents. Organic light emitting diodes (OLEDs) are being inkjet printed to produce television screens. Polymers are being printed to produce final products eliminating the need for expensive machining steps. Even living cells are being printed into functioning tissues and organs.

This poster will show how basic chemical engineering knowledge, e.g., knowledge of thermodynamics, vapor-liquid equilibria, fluid flow and heat transfer can help understand inkjet printing and guide its advancement into the future.

A Case Study in Step by Step Process Development

Sadeka Onam*, Kenric Marshall, and Amarnath Singh, The Dow 91成人短视频 Company

At commissioning, a chemical manufacturing plant represents the end results of years, and sometimes decades, of research and continuous improvement in design. Each plant is built with a goal of maximizing the economic return for that investment. However, it is doubtful if any plant has ever been built that did not contain an opportunity to reduce cost or otherwise improve performance at some point in its lifetime. Even if a plant were to be built that represented the state of the art in performance by every measure, the reality that markets are not static and scientific innovation inexorably advances means that opportunities to maximize the value from these expensive assets will continue to be created.

Factors that create opportunities for value creation or preservation will be presented. A challenge for process researchers is that project timing and resource availability invariably complicate the problem-solving process. A series of examples will be discussed that demonstrate the use of available tools (modeling, lab-scale experimentation, pilot-scale development) to achieve process improvement goals.

Data-Driven Modeling: Two Methodological Generalizations

Bing Zhang* and Christos Georgakis, Tufts University

This poster presentation focuses on the development of data-driven models for batch 91成人短视频 and pharmaceutical processes. It describes two generalizations of the classical design of experiments (DoE) methodology, the long-standing data-driven modeling methodology of choice. The first generalization enables the design of experiments with time-varying inputs and it is called Design of Dynamic Experiments (DoDE). The second generalization enables the development of a dynamic response surface model (DRSM) when time-resolved measurements are available. We will discus how both advances are able to contribute significantly to the modeling, optimization, and understanding of processes for which a knowledge-driven model is not easily at hand. Concerning reacting systems we utilize the DRSM models developed for each species to systematical investigate the stoichiometries supported by the data and the development of kinetic models. Applications to industrial examples with Sunovion, Dow and Pfizer will demonstrate the benefits of the DoDE and DRSM approaches.

Process Modeling and Optimization to Minimize Drying Times of Pharmaceutical Solids

Akash Kothari*, David am Ende, Jerry Salan, Sian Jones, Seth Huggins, and Andrew Cosbie, Nalas Engineering

Drying of pharmaceutical intermediates and API鈥檚 is commonly performed in agitated filter driers.  This unit operation is frequently the rate-limiting step in a manufacturing process train.  It is therefore important to understand the drying rates to optimize the drying time prior to the scale-up. This poster discusses the experimental and modeling approach used to predict the drying time for five different pharmaceutical compounds in a 250L Agitated Filter Dryer (AFD).   Lab studies were performed in a 5-Liter Agitated filter drier where mass of wet-cake and condensate volumes were obtained during drying.  Drying models were then employed using Dynochem, to regress the drying parameters from the experimental data for each of the compounds.  The drying models were then use to optimize the drying rates and predict drying times in a 250 Liter scale agitated filter drier.  The results from these models were used for planning and scheduling of drying operation at production scale.  The drying data and Dynochem models as well as the predicted drying times will be presented.