Using Nanomotion to Test for Antibiotic Resistance | AIChE

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Using Nanomotion to Test for Antibiotic Resistance

June
2023

A new rapid test uses a simple optical microscope to determine whether bacteria exhibit resistance to antibiotics.

The test capitalizes on the fact that all living cells, from microorganisms like bacteria and yeast to individual plant cells, vibrate on a nanoscale level. Some of these movements may come from obvious sources like the beating of flagella or cilia, according to Sandor Kasas, a scientist in the laboratory of biological electron microscopy at the 脡cole Polytechnique F茅d茅rale de Lausanne. But even cells without these moving appendages give off tiny movements. These may come from the opening and closing of ion channels in the cellular membrane or from other changes happening in cellular proteins as part of the cell鈥檚 metabolism.

new rapid test uses a simple optical microscope


(a) All that is required to conduct the new nanomotion detection test are a low-cost optical microscope and a mobile phone. (b) Here, E. coli bacteria are being viewed through the microscope. (c) The same field of view is shown, but here, false colors highlight bacterial displacement. Red is high-amplitude motion (proving the bacteria is still alive) and blue...

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