At the Univ. of Toronto (U of T), researchers are using a novel technique to measure immunity to COVID-19. With just one pinprick of blood, the assay can detect coronavirus antibodies in under one hour 鈥� the quickest and least expensive method yet.
The researchers call their test the serological assay based on split nanoluciferase, or SATiN, for short. It measures immunoglobin G antibodies (IgGs), specifically those that work against SARS-CoV-2. In the presence of coronavirus-specific IgGs, the SATiN mechanism lights up, indicating immunity against COVID-19.
SATiN is based on nanoscale luciferase (NLuc), a luminescent enzyme that detects coronavirus IgGs by splitting into three fragments: 尾9, 尾10, and 螖11S. In a blood sample, 尾9 binds to protein G, a molecule specific to immunoglobin, and 尾10 binds to the unique spike (S) protein native to SARS-CoV-2. The dual binding of 尾9 and 尾10 triggers the 螖11S fragment to luminesce, signifying the presence of coronavirus antibodies.
The scientists tested their...
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