Bacterial cells living at interfaces usually have neighbors of many different species and are able to organize themselves into complex structures named biofilms. A more effective management of these structures requires both an in-depth characterization of the spatial location of the individual cells and the use of molecules that are able to control their growth. In here, I will discuss the application of nucleic acid mimics (NAMs), also known as nucleic acid analogues, to study and manage these multispecies biofilms. More specifically, I will provide examples of works that are currently being carried out within our research team and that include: 1) coupling NAMs and fluorescence in situ hybridization for a more robust detection of pathogens within biofilms; 2) combination of NAMs and delivery vectors such as liposomes and cell-penetrating peptides for a more efficient treatment of individual microbial cells within biofilms.
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